After hematopoiesis was reestablished, we observed that the mice receiving Mlkl−/−Casp8ΔE385/ΔE385 bone marrow developed splenomegaly, whereas the spleen of Ripk3−/−Casp8ΔE385/ΔE385 recipients showed no difference (Fig. S6B). Here, MLKL is linked to Splenomegaly.