RIPK1 and lymphopenia: Moreover, Lymphopenia and myeloid bias in Ripk3−/−Casp8ΔE385/ΔE385 mice were largely suppressed in Ripk1+/−Ripk3−/−Casp8ΔE385/ΔE385 mice but not in Ripk1K45A/K45ARipk3−/−Casp8ΔE385/ΔE385 mice, revealing a previously unknown role of the dosage of RIPK1 instead of RIPK1 kinase activity administered to the mice in maintaining immune cell homeostasis in Ripk3−/−Casp8ΔE385/ΔE385 mice.