CASP8 and lymphopenia: Unlike Casp8−/−Ripk3−/− and Casp8−/−Mlkl−/− mice, which resemble the human ALPS [11] and impair cytokine response [33], we found that Casp8ΔE385/ΔE385Ripk3−/− and Casp8ΔE385/ΔE385Mlkl−/− mice develop hematopoietic cell-intrinsic lymphopenia and myeloid bias (Figs. 5, 6).