Consistently, myeloid bias and lymphopenia in the spleen and lymphopenia in the bone marrow were also significantly relieved in Ripk1+/−Ripk3−/−Casp8ΔE385/ΔE385 mice compared to those in Ripk3−/−Casp8ΔE385/ΔE385 mice (Fig. 6B). Here, RIPK1 is linked to lymphopenia.