Importantly, the complete blood count results showed increased WBC and lymphocyte in the peripheral blood of Ripk1+/−Ripk3−/−Casp8ΔE385/ΔE385 mice compared to WT mice (Fig. 6C), suggesting that lymphopenia and myeloid bias in Ripk3−/−Casp8ΔE385/ΔE385 mice were largely alleviated by halving RIPK1 dosage. This evidence concerns the gene RIPK1 and lymphopenia.