CXCR5 and systemic lupus erythematosus: Given that TFH cells can contribute to the pathogenesis of SLE, as well as previous research indicating that autoimmune-derived TFH cells are susceptible to A2A receptor-mediated depletion, we analyzed spleens from MRL/lpr mice for the presence of CXCR5+PD1+CD4+ T cells.