It may be due to the different mechanisms among the development of CRC, perhaps there are other genes not HERC3 that play an important role in the development of disease in this small group of patients, perhaps it may also be due to the different tumor genomic type in this group of patients, resulting in different expression trends of HERC3 from other patients, however, based on the available clinical data, we did not find a specific tumor genomic type for this group of patients, maybe an unidentified one, which is one of the directions of our future research. Here, HERC3 is linked to colorectal carcinoma.