Mll1 promotes a highly proliferative regenerative cell state which renders intestinal epithelial cells susceptible for tumorigenesis (Heuberger et al, 2021), maintains intestinal cancer stem cells, and promotes Wnt-induced tumorigenesis by antagonizing the polycomb repressive complex 2 (PRC2)–mediated repression of stem cell genes (Grinat et al, 2020). Here, KMT2A is linked to intestinal cancer.