Of the tested compounds, improved cell survival at two different concentrations was only observed with sodium phenylbutyrate (PBA), which improved cell survival of the WT and ADTKD–SEC61A1 cells at concentrations of 0.5 and 1 mM (Fig S5C–F). Here, SEC61A1 is linked to autosomal dominant medullary cystic kidney disease with or without hyperuricemia.