Thus, in assaying the protein abundance landscape of the ADTKD–SEC61A1 cells, we identified reduced levels of crucial regulators of calcium homeostasis like Orai1 and SERCA2 in the presence of the dominant Sec61α-V67G or T185A mutation. This evidence concerns the gene ORAI1 and autosomal dominant medullary cystic kidney disease with or without hyperuricemia.