REN and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: To date, multiple dominant mutations (e.g., W10R, L16R, and C20R) in the signal peptide of renin have been found to cause ADTKD–REN, adhering to the gene-based terminology (Živná et al, 2009, 2020; Bleyer et al, 2010; Beck et al, 2011).