Our transcriptome analysis further confirmed the involvement of CCR1 and CCR5 in the polarization of myeloid cells, showing that HSPCs differentiated by tumor derived factors in the presence of maraviroc and B×471 shared a signature of classical neutrophils and clustered with CD11b+ cells from the bone marrow of naïve mice, whereas the ones differentiated without antagonists showed an MDSC signature and clustered with tumor-infiltrating myeloid cells. The gene discussed is CCR5; the disease is neoplasm.