The two groups exhibited significant differences in medial canthus involvement (p=0.004), tumour presentation pattern (p=0.036), greatest basal diameter (p=0.003), orbital invasion at presentation (p<0.001), PNI (p=0.015), Ki-67 percentage (p<0.001), T category (p=0.002) and initial treatment (p<0.001). The gene discussed is MKI67; the disease is neoplasm.