Previous studies have demonstrated that the T category of tumour, node, metastasis (TNM) staging system is often used to predict metastasis of eyelid SC based on the significant correlations between the T category and metastasis.6–8 14 However, T category is mainly determined by tumour size, and some other factors, including medical history, growth pattern and pathological features, such as multicentric origin, pagetoid spread, perineural or perivascular invasion, Ki-67 and histology differentiation, have not been included. This evidence concerns the gene MKI67 and neoplasm.