Taken together, the reported reciprocal regulation between CRISP and PSP94 levels during prostate cancer progression, the antifungal activity of PSP94, the sterol binding activity of CRISP proteins, and the calcium sensitivity of the interaction between CRISP and PSP94 suggest that a complex interplay between these activities is crucial for preventing malignant development of the prostate tissue. Here, MSMB is linked to Familial prostate cancer.