RYR3 and breast carcinoma: The GO biological processes of ACVR2A, KIT, and FAT4 are skeletal system development, RYR3 and EGFR are in the Calcium signaling pathway enrichment, the GO molecular functions of RYR3 and FAT4 are calcium ion binding and the GO molecular function of RYR3 is calcium-induced calcium release activity [33], and the most common metastasis of breast cancer is bone metastasis, so the enrichment of these GO biological processes, GO molecular functions and key pathways seems to explain why 85% of patients with advanced breast cancer have bone metastases [31, 34].