TGFBI exerted as a tumor suppressor or enhancer in cancer progression is an extracellular matrix (ECM) protein that is associated with a number of ECM proteins such as fibronectin, biglycan, decorin, and several types of collagen and functions as a ligand to modulate cell adhesion and migration via various types of integrins [22]. The gene discussed is TGFBI; the disease is neoplasm.