MAPT and supranuclear palsy, progressive, 1: Next, we studied the effects of D-peptides in inhibiting the aggregation of physiologically relevant full-length Tau carrying disease-causing mutations such as ΔK280 (in R2 of RD), A152T (in proline-rich domain), and P301L (in R2 of RD) which are found in frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), progressive supra-nuclear palsy (PSP), and AD patients.