We also ran a differentially methylated regions analysis using DMRcate. In this study, we found 11 CpGs in a specific genome region overlapping with the gene BLCAP. NMIBC patients without tumor recurrence or death within 10 years had a higher mean of methylation levels for this region compared with NMIBC patients with tumor recurrence or death within 10 years, and one CpG in this region was significant (FDR = 2.63 × 10−14) (Additional files 6, 7: Figure S7). This evidence concerns the gene BLCAP and neoplasm.