ALKBH5 and hereditary clear cell renal cell carcinoma: Similarly, hypoxia and HIFs elevate ALKBH5 expression in lung adenocarcinoma cells [90], renal cell carcinoma cells [105], endometrial cancer stem cells [104] and pituitary adenoma cells [109], leading to invasive tumor phenotype, enhanced tumor initiation capacity, sustained stem-like state and poor clinical outcomes.