Numerous studies have revealed the anti-inflammatory effects of Met-R, which functions by inhibiting CCR1, and the subsequent suppression of proinflammatory cytokine released in several diseases, including multiple sclerosis (MS), autoimmune encephalomyelitis (EAE) [26], atherosis [46], arthritis [47], and herpes simplex virus infection [48]. This evidence concerns the gene CCR1 and arthritic joint disease.