Endothelial SRC phosphorylation could lead to the degradation of transmembrane protein vascular endothelial‐cadherin (VE‐cadherin), as well as the breakdown of blood‐brain barrier (BBB) integrity, thus inducing brain edema after ICH through the PAR1/p-SRC/p-PAK1 signaling pathway in a rat model of hydrocephalus [50]. The gene discussed is PAK1; the disease is Hydrocephalus.