In addition, polarized M2 macrophages produce IL-6 to promote the phosphorylation of the threonine 243 of phosphoglycerate kinase 1 (PGK1T243) mediated by 3-phosphoinositide-dependent protein kinase 1 (PDPK1) in tumor cells, promoting glycolysis and tumor progression. Here, PGK1 is linked to neoplasm.