When phosphatase and tensin homolog (PTEN) is accumulated on the plasma membrane through the mediation of TCR and CD28, acylglycerol kinase (AGK) positively regulates PTEN phosphorylation at the site of Ser380, Thr382, and Thr383 and inhibits the phosphatase activity of PTEN in CD8+ T cells, promoting activation of phosphatidylinositol-3-OH kinase (PI3K)-mTOR and mediating glycolysis and anti-tumor function. The gene discussed is MTOR; the disease is neoplasm.