LRG1 and familial pancreatic carcinoma: Indeed, epidermal growth factor receptor (EGFR) has been shown to mediate LRG1 activity in pancreatic cancer cells [49], metastatic melanoma cells [90], and corneal epithelium during wound repair [64], whereas the IL-6/STAT3 axis appears to modulate LRG1-driven neutrophil chemotaxis [57].