LRG1 and cancer: As widely discussed across this review, LRG1 orchestrates pathological blood vessel formation [29] by enhancing proliferation, migration and invasion of endothelial cells [35], as well as the expression of several pro-angiogenic factors including TGFβ, VEGFA and Angiopoietin-1, in both endothelial [35, 190] and cancer cells [197].