In CRC, for example, LRG1 has been shown to inhibit apoptosis and modulate the EMT of tumour cells through expression of the transcription factors RUNX1 [50] and HIF-1α [197], whose association with TGFβ and contribution to tumour growth are well-established (Fig. 6). This evidence concerns the gene TGFB1 and colorectal carcinoma.