As observed in the heart, while LRG1 might play some beneficial functions on tissue revascularization following infarction, ectopic expression of LRG1 using an AAV vector exacerbated the ischemic/reperfusion injury caused by transient MCAO with regards to infarction volume and neurological score, which is in line with its highly pro-inflammatory nature [218]. Here, LRG1 is linked to infarction.