Indeed, several in vitro studies described IL-1β, IL-17, TNFα, IL-4, IL-33 and IL-10 as additional LRG1 regulators in hepatoma cells [30], endothelial cells [31], bronchial epithelial cells [15] and “alternatively activated” (M2) macrophages [32] (Fig. 4). This evidence concerns the gene LRG1 and hepatocellular carcinoma.