LRG1 and cancer: Moreover, the observation that exogenous LRG1 ameliorates cell viability per se, regardless of Cyt c addition [42], demonstrates that it can exert protective functions not only through the clearance of pro-apoptotic factors, such as Cyt c, but also via direct modulation of alternative survival pathways, as confirmed by various studies on cancer and discussed later in this review [48–50].