SLC26A4 and deafness: Some deafness gene screening techniques can screen for hot-spot variants in SLC26A4. However, targeted screening tests might miss rare variants of SLC26A4. In patient 12751, we detected a compound heterozygous variant, c.589G>A/ c.1238A>G, which was not in the variant hot-spots of SLC26A4. Therefore, for patients with deafness, it is best not to use deafness gene screening technology.