HSPG2 and neoplasm: Notably, the PLC/PRF/5 xenograft tumors were insensitive to DBPR114 (TGI = 25.7%) but highly sensitive to sorafenib (TGI = 85.5%) in vivo, and DBPR114 was three times more potent than sorafenib in inhibiting PLC/PRF/5 tumor cell growth in vitro.