As shown in Table 3, multivariable logistic regression analysis revealed that serum CgA (OR 1.403, 95% CI 1.202–1.637, P < 0.001) and BUN (OR 1.299, 95% CI 1.045–1.616, P = 0.019) were independently associated with the occurrence of early DN when adjusted for age, sex, known diabetes duration, SBP, DBP, FBG, HbAlc, TC, TG, HDL-C, LDL-C, sUA, BUN, sCr and CgA. The gene discussed is CGA; the disease is liver dysplastic nodule.