Markers of tubular injury, such as Kidney Injury Molecule-1 (KIM-1), Neutrophil Gelatinase-Associated Lipocalin (NGAL), Liver-type Fatty Acid Binding Protein (L-FABP), Monocyte Chemoattractant Protein-1 (MCP-1), and Epidermal Growth Factor (EGF), have been extensively investigated as prognostic biomarkers in DN. This evidence concerns the gene LCN2 and liver dysplastic nodule.