The multivariate logistic regression analyses in patients with T2DM between the normoalbuminuria group and the microalbuminuria group revealed that CgA levels and not eGFR were independently associated with microalbuminuria, which suggests that CgA reflects progression of renal damage even at an early stage without apparent reduction of kidney function, and thus might represent a sensitive marker of DN. This evidence concerns the gene CGA and liver dysplastic nodule.