AFP and neoplasm: In addition, serum tumor markers, like carcinoembryonic antigen (CEA), lactate dehydrogenase (LDH), carbohydrate associated antigen 19-9 (CA19-9), cancer antigen 125 (CA125) and alpha-fetoprotein (AFP), are more convenient and cost-effective detections than other approaches, they are extensively used in monitoring disease condition, assessing treatment effect, estimating prognosis and predicting recurrence [4].