CD8A and infection: Moreover, beyond the metabolic improvement, very-low-carbohydrate diets have shown to be immunomodulatory in mouse models, as these were found to be capable of enhancing tumor-reactive CD8+ T cell and NK cell activity in glioblastoma [49] and were protective against influenza virus via an increased number and activity of protective γδ T cells in the lungs [50], a finding that was confirmed on infection with the murine equivalent of SARS-CoV-2 [51].