The main findings of the present review include: (1) allergic reactions may be complicated with acute coronary syndrome, (2) many patients with KS present in a young age and have no risk factors of CAD or history of prior allergic reaction, (3) even though most of the patients present with ST-elevation myocardial infarction, only a small fraction will require coronary revascularization, (4) many inflammatory biomarkers including tryptase, eosinophils and IgE have been found to be elevated and(5) no algorithm for the management of KS is currently available. Here, IGHE is linked to allergic disease.