Studies have shown that TRIM21 participates in STING-mediated negative feedback regulation of the DNA sensor IFI16, a member of the interferon inducible-200 (IFI200) family, which leads to the degradation of IFI16 via the ubiquitin–proteasome pathway, and thus balancing the overproduction of IFN-I caused by a virus infection [32]. This evidence concerns the gene TRIM21 and viral infectious disease.