HMGCR and viral infectious disease: On the other hand, intracellular host restriction factors, such as 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), complement component 1Q subcomponent-binding protein (C1QBP), and tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein (14-3-3β/α, YWHAB), play important roles in resisting virus infection [1,2,12,13,14].