Focus is given to the role of proteins encoded by genes m04 and m06 of the m02 gene family and m152 of the m145 gene family in positive and negative regulation of MHC-I trafficking and cell surface presentation of peptide-loaded MHC-I (pMHC-I) molecules for recognition by antivirally protective CD8+ T cells during acute and latent infection. The gene discussed is CD8A; the disease is disease arising from reactivation of latent virus.