CFTR and cystic fibrosis: P. aeruginosa OMVs can (i) prime host tissue surfaces for bacterial adhesion [5], (ii) facilitate the removal of competing bacteria from the environment during infection, as well as (iii) reduce CFTR (cystic fibrosis transmembrane conductance regulator) Cl− secretion from cystic fibrosis bronchial epithelial cells, thus reducing the bacterial clearance from the lungs [13,27].