Furthermore, MSC loaded with oHSV–TRAIL (TNF-related apoptosis-inducing ligand) (MSC-oHSV-TRAIL) induced the apoptosis-mediated killing of GBM cells resistant to oHSV and TRAIL and efficiently prolonged the median survival of orthotopic tumor-bearing mice in immune-deficient GBM models. The gene discussed is TNFSF10; the disease is glioblastoma.