SLC16A3 and central nervous system cancer: Notably, significant increases to lactate exporter MCT4 expression were seen (Figure 6 and Figure 8, Supplementary Figure S5) and may account for the increased extracellular concentrations of lactate MCT4 expression is elevated in GBM, has been positively correlated with the pathological grades of glioma, and was found to promote GBM migration [57].