Italians and Spanish had a polymorphism in CXCR6, known as rs11385942, that contains an insertion-deletion of GA/A and was related to a decrease in CXCR6 and overexpression of solute carrier family 6 member 20 (SLC6A20) and leucine zipper transcription factor-like 1 (LZTFL1) in the lungs of COVID-19 patients that required mechanical ventilation [176]. The gene discussed is CXCR6; the disease is COVID-19.