The MHCII molecules of these mice had a traffic toward late endosome/lysosomes, whereas MHCII molecules of *0402 mice moved toward early lysosomes [234], indicating that although some MHC polymorphisms are associated with autoimmune diseases, the same MHC molecules can play a pivotal role in the clearance of some viral infections. The gene discussed is HLA-C; the disease is viral infectious disease.