Recent studies have identified deleterious variants involved in IFN type I signaling, including variants of TLR-3; transcription factors, such as STAT1 and STAT2; interferon regulatory factors, such as IRF1 and IRF7; and IFN-α receptors, such as IFNAR1 e IFNAR2, are associated with inadequate immune responses after vaccination as well as the most severe cases of COVID-19. Here, STAT2 is linked to COVID-19.