CD4 and multiple sclerosis: CD4+CD8+ DP T cells have been described in several pathological conditions in comparison to normal individuals [28]; for example, expansion of DP cells has been observed in autoimmune diseases (e.g., Myasthenia gravis, Rheumatoid arthritis, multiple sclerosis, Kawasaki diseases, and systemic sclerosis), infectious diseases (e.g., HIV and EBV), and cancers (e.g., melanoma, lymphoma) [28].