CHMP4B and infection: Lastly, a recent study from the same group of investigators provided additional evidence for the role of the ESCRT-III complex in nuclear egress by demonstrating that infection with a replication competent HSV-1 containing a mutation in the disordered domain of pUL34 led to the altered localization of the NEC-infected cells, loss of pUL34 colocalization with CHMP4B of the ESCRT-III complex, and the accumulation of enveloped capsids in the PNS [68].