These results, together with the genotype combinations observed from phased data retrievable from the 1000 Genomes Project data (Supplementary Figure S7) strongly suggest a putative interaction effect that rs1830298 and rs3769821 have in maintaining a high level of CASP8 transcript, which is lost in individuals carrying the breast cancer risk allele in at least one of the two variants. This evidence concerns the gene CASP8 and breast carcinoma.