The first community contains variants rs199499 and rs7207400, that are reported in the GWAS catalogue as associated to trait Alzheimer's disease in APOE ε4- carriers and that present a low LD in the general population (r2 = 0.18) and moderate LD (r2 = 0.52) in the European population. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.