When subgroup analysis was carried on the relationship of SHP2 and DFS, the results indicated that higher expression of SHP2 could predict longer DFS in colorectal carcinoma (HR: 0.45; 95% CI, 0.23–0.88; P = 0.019), while predict shorter DFS in hepatocellular carcinoma (HR: 1.38; 95% CI, 1.01–1.88; P<0.05). Here, PTPN11 is linked to colorectal carcinoma.