This meta-analysis suggested that high SHP2 expression was positively correlated with early clinical stage in hepatocellular carcinoma, not associated with clinical stage in laryngeal carcinoma, pancreatic carcinoma, gastric carcinoma, esophagus carcinoma, colorectal carcinoma, and thyroid carcinoma. The gene discussed is PTPN11; the disease is exocrine pancreatic carcinoma.