Moderate anaemia and log CRP were associated with elevated SHR (10.3beats/min, 95%CI: 7.3, 13.5 and 7.0 beats/min, 95% CI: 5.5, 8.6) in HIV-infected only (interaction p = 0.04 and p<0.001). The gene discussed is CRP; the disease is anemia (phenotype).