Table 1 presents the numbers of girls with and without CPP in the discovery and validation data sets. As shown in Table 1, 25 variables significantly differed between girls with and without CPP; exceptions were the Z-scores of weights and BMI and the baseline LH-to-FSH ratio (Table 1). Besides, girls in the external validation dataset were older than girls in the internal validation dataset (8.4 ± 1.1 vs. 7.5 ± 1.4, p<0.001). This evidence concerns the gene PLOD1 and central precocious puberty.