Infection associated genes encoding secreted proteins that showed lower relative expression > 1fold, log2 in Holstein cells were ADMATS18, C1QTNF6 (complement C1q tumour necrosis related protein: anti-inflammatory), SPOCK2 (ERK signalling pathway, pro-cancer), TNFSF10 (cytokine that induces apoptosis in transformed cells) and CCL5 (chemokine involved in inflammation and immuno-regulation; chemo-attractant for blood monocytes and memory T helper cells). The gene discussed is C1QTNF6; the disease is infection.