The genotype (Thr/Thr, Thr/Met and Met/Met) frequency distribution of the XRCC3-Thr241Met variant was found to be 69.4%, 27.2% and 3.4% in the controls and 63.1%, 32.2% and 4.7% in BC cases respectively (Table 3). The gene discussed is XRCC3; the disease is breast cancer.