TBC1D1 and metabolic dysfunction-associated steatotic liver disease: Here, we reveal a previously unrecognized role of TBC1D1 in the control of hepatic lipid storage through composite actions involving both direct binding and Rab2A-dependent regulation of PPARγ (Fig 7G), which not only further demonstrates the importance of TBC1D1 in lipid metabolism but also links this protein to another metabolic disease NAFLD.