Many studies have shown that genetic mutations can regulate the progression of NAFLD, including patatin-like phospholipase domain–containing 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), and membrane-bound O-acyltransferase domain–containing 7 (MBOAT7) [3]. This evidence concerns the gene TM6SF2 and metabolic dysfunction-associated steatotic liver disease.