Amongst males, an increased risk of prostate cancer was observed for bioavailable testosterone (OR = 1.22, 95% CI: 1.08, 1.37) but not in relation to total testosterone (OR = 0.97, 95% CI: 0.86, 1.07), or SHBG (OR = 0.91, 95% CI: 0.76, 1.09) (Fig 3B). The gene discussed is SHBG; the disease is Familial prostate cancer.