Amongst females, an increased risk of breast cancer was observed with increasing total (OR = 1.15, 95% CI: 1.07, 1.23 per SD) and bioavailable (OR = 1.10, 95% CI: 1.01, 1.19 per SD) testosterone, but not in relation to SHBG (OR = 0.99, 95% CI: 0.89, 1.11 per SD) (Fig 3A). The gene discussed is SHBG; the disease is breast cancer.