ARHGAP42 and Hypertension: As an example of the trait relevance of these dynamic eQTLs, one dynamic eQTL variant, rs1234988, has previously been implicated by GWAS to be associated with hypertension (p = 2.5e-35), and was detected as a dynamic eQTL for ARHGAP42, a Rho GTPase which has previously been identified as a critical regulator of vascular tone and hypertension in mice (Figs 3A, 3B and S12, [50,51]).