To further determine the causal role of DF-induced endothelial TXNDC5 in atherosclerosis, we generated a mouse line [Cdh5-Cre/ERT2::Txndc5fl/fl (Txndc5∆ECKO)] in which Txndc5 can be deleted in adult vascular endothelium by a tamoxifen-induced Cre recombinase driven by the endothelium-specific Cdh5 (VE-Cadherin) promoter (19). The gene discussed is TXNDC5; the disease is atherosclerosis.