NOTCH1 and neoplasm: The use of an independent mouse model of T-ALL using overexpression of an oncogenic truncated allele of NOTCH1 transcription factor (NOTCH1-ΔE) in hematopoietic progenitors (33), coupled to transplantation into immunocompromised mouse recipients, also showed inhibition of tumor growth upon E7107 treatment, as indicated by the reduction in spleen size (Fig. 1H).