The use of an independent mouse model of T-ALL using overexpression of an oncogenic truncated allele of NOTCH1 transcription factor (NOTCH1-ΔE) in hematopoietic progenitors (33), coupled to transplantation into immunocompromised mouse recipients, also showed inhibition of tumor growth upon E7107 treatment, as indicated by the reduction in spleen size (Fig. 1H). Here, NOTCH1 is linked to acute lymphoblastic leukemia.