Chronic overexpression of Il1b in brain areas such as the hippocampus have been implicated in impaired spatial memory (Moore et al. 2009) and in contextual fear memory (Matousek et al. 2010) in conditional transgenic mice, and with seizure susceptibility in animal models of sleep fragmentation (Grubac et al. 2021) and prostatitis (Sutulovic et al. 2019). This evidence concerns the gene IL1B and medical procedure.