In four patients (#1, #3, #7, #9), who had athyreosis and an eutopic thyroid gland, we found double heterozygous missense variants in the TSHR and GLIS3 (patient 1), DUOX2 and SLC26A4 (patient 3), in DUOX2 and TPOgenes (patient 7), and DUOX2 and TG (patient 9), configuring an oligogenic origin of the CH, as previously described by our group (21). The gene discussed is DUOX2; the disease is athyreosis.