UBE2I and cervical carcinoma: Inhibition of LMP1‐induced SUMOylation abrogates KAP1 function and disrupts the latency of EBV.[72] HPV E6 proteins are another example of an interaction with UBC9.[73] E6 can bind to UBC9 and mediate UCB9 proteasome degradation, and the resulting reduction in UCB9 causes decreased host SUMOylation, and accelerates the development of cervical cancer.[73] There are multiple mechanisms by which viruses utilize host E2 SUMO‐conjugating enzymes.