SENP2 and viral infectious disease: A recent study suggested that LMP1 inhibits the ubiquitination of SENP2, which results in stabilizing SENP2 expression, suppressing SENP2 activity, and reducing the nuclear localization of SENP2.[85] Finally, the functional consequence of SENP2 ubiquitination is the decreased deSUMOylation of cellular proteins, which contributes to the global increase in SUMOylated proteins during latent EBV infections.[85] Viral infection can also result in the suppression of viral genome replication by modulating the host SUMOylation machinery.