The mechanism by which CFTR modulates raft size remains to be determined; however, cholesterol (White et al., 2007) and the ω-3 polyunsaturated fatty acid DHA (Freedman et al., 1999) may be relevant, as they influence raft stability in model and biological membranes and their levels are abnormal in CF (Levental et al., 2016). The gene discussed is CFTR; the disease is cystic fibrosis.