MTHFR and hypertensive disorder: People with a prothrombotic state due to Hcy load have fluctuations in BP.[8] H-type hypertension influences BP and cardiovascular health outcomes.[20,21] Other studies have highlighted that MTHFR C677T genotyping is important.[22,23] In a recent study of hypertension, hypertension in a small population of people was found to be related to a prothrombotic state,[24] which suggests that the prothrombotic state is a negative influencing factor in hypertension.[25] In this study, 36/110 participants had high prothrombotic state scores.