CD274 and colorectal carcinoma: Furthermore, determining the evaluation of adjuvant chemotherapy in improving DFS or OS in relation to PD-L1 expression might prove challenging in the microsatellite stable and MSI subgroups of GI malignancies.[17,19,22] The complex relationship between the prognosis for nonmetastatic CRC and PD-L1 expression was further clarified based on the results of our study.