CD274 and neoplasm: Accordingly, PD-L1 expression in our study with the SP142 clone mostly occurred in the ICs of the tumor-related stroma, with a particular sensitivity of expression in the ICs and not just any tumor cells.[19,23] In addition, many previous studies used cut-off values of >5% or <5% to define the positive or negative expression of PD-L1; however, in this study, we used IC density of PD-L1 expression as a continuous variable to analyze the prognosis.