At present, different studies have reached a consensus that distant metastasis that leads to disease recurrence poses the most severe challenge to the management of nasopharyngeal carcinoma, resulting in unfavorable prognosis.[45,46] In this study, there were 5 studies that reported DMFS as the study outcome, and pooled results demonstrated that EGFR overexpression was independent of the DMFS in nasopharyngeal carcinoma patients. Here, EGFR is linked to nasopharyngeal carcinoma.