MTHFR and Dravet syndrome: At least three different meta-analyses of those studies, performed between 2013 and 2014, addressed whether MTHFR C677T and/or A1298C polymorphisms are associated with the maternal risk for having a child with DS, and despite that significant associations emerged for the C677T one in the overall population, the different inclusion criteria selected by the authors yielded conflicting or inconclusive results after subgroup stratification according to ethnicity.[23–25]