Using data from a pilot study of 179 children (none of whom was a malaria case) at the Manhiça and Bagamoyo sites, Moncunill et al. previously showed that MAL067 RTS,S/AS01 recipients have higher month 3 CSP-specific and HBS-specific CD4+ T-cell polyfunctionality scores than comparator recipients (Moncunill et al., 2017a). This evidence concerns the gene CD4 and malaria.